IMPAD1 functions as mitochondrial electron transport inhibitor that prevents ROS production and promotes lung cancer metastasis through the AMPK-Notch1-HEY1 pathway
نویسندگان
چکیده
منابع مشابه
Antimycin A as a mitochondrial electron transport inhibitor prevents the growth of human lung cancer A549 cells.
Antimycin A (AMA) inhibits mitochondrial electron transport between cytochromes b and c. We evaluated the effects of AMA on the growth of human pulmonary adenocarcinoma A549 cells in relation to cell cycle and apoptosis. Treatment with 2-100 microM AMA significantly inhibited the cell growth of A549 for 72 h. DNA flow cytometry indicated that AMA slightly induced a G1 phase arrest of the cell c...
متن کاملLoss of AMPK activation promotes the invasion and metastasis of pancreatic cancer through an HSF1‐dependent pathway
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with a mortality rate that closely parallels its incidence rate, and a better understanding of the molecular and cellular mechanisms associated with the invasion and distant metastasis is required. Heat shock factor 1 (HSF1) is a very highly conserved factor in eukaryotes that regulates the protective heat shock response. Here, we s...
متن کاملHepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) production.
Hepatitis C infection causes a state of chronic oxidative stress, which may contribute to fibrosis and carcinogenesis in the liver. Previous studies have shown that expression of the HCV core protein in hepatoma cells depolarized mitochondria and increased reactive oxygen species (ROS) production, but the mechanisms of these effects are unknown. In this study we examined the properties of liver...
متن کاملNotch1 pathway-mediated microRNA-151-5p promotes gastric cancer progression
Gastric carcinoma is the third leading cause of lethal cancer worldwide. Previous studies showed that Notch1 receptor intracellular domain (N1IC), the activated form of Notch1 receptor, promotes gastric cancer progression. It has been demonstrated that a significant cross-talk interplays between Notch pathways and microRNAs (miRNAs) in controlling tumorigenesis. This study identified an introni...
متن کاملMitochondrial Bioenergetics and ROS Production
immersed in a medium containing 21% oxygen, a highly reactive molecule. Fortunately for us, this impediment to life has been turned back on itself and has actually been harnessed by the cell to generate the stored chemical energy necessary to meet the major demands of cell physiology. Mitochondria are the organelles providing this protection, compartmentalizing and controlling the oxidation of ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Letters
سال: 2020
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2020.04.025